New Technology Showcase

SILICONE MOLDING MANUFACTURING

AdvantaPure has expanded its clean room manufacturing facility to meet increasing demand. It has increased production capabilities by converting space and moving some manufacturing operations to other areas. The transformed areas house stations forthe manufacture ofsingle-use silicone manifolds and the company's BioQosure Systems. AdvantaPure repurposed its hose assembly area into a new clean room. The space now has HEPA filtration, sealed doors, gowning rooms, and restricted personnel usage. The clean room is third-party certified to ISO Class 7 (Class 10,000). The company offers manifolds consisting of tubing orreinforced hose;fittings inT,cross, Y,and reducer styles; and components such as filters, bags, and aseptic connectors. BioClosure silicone stoppersjrue Union and GL45 inserts, and caps are manufactured for glass, plastic, ormetal containers and are available in solid or with tubing inserts. AdvantaPure, 215.526.2151, www.advantapure.com.

SINGLE-USE BIOPROCESSVESSELS

Integrity single-use bioprocess vessels (BPVs) are available from ATMI LifeSciences in both 2-D and 3-D bag formats, and are manufactured using the company's Integrity TK8 polymer film. The BPVs have been designed for use in the storage and transfer of dean or sterile liquids that are critical to biotechnology processes. Integrity BPVs have been developed to meet the demand for cost-effective, scalable, single-use storage containers that are compatible with ATMI's single-use mixing and bioreactor technologies. The single-use vessels can help companies reduce risk while driving down costs in comparison with traditional stainless steel equipment. Designed for deployment across a wide variety of applications, the 2-D and 3-D BPVs range in sizes up to 3,000 L and are configurable to a broad range of end-user processes. ATMI LifeSciences, 859.263.1135, www.atmi-lifesciences.com/ html/formulaire.php.

ECO ULTRAFILTER

Sartorius Stedim Biotech's Sartocon ECO is based on Hydrosart ultraf iIter technology that uses stabilized polymer membranes based on hydrophilic regenerated cellulose. Hydrosart membranes enable high yields by minimizing protein binding to the membrane and are thus virtually nonfouling. Sartocon ECO features high stability under strongly alkaline conditions and over wide temperature ranges, so it is easy to clean and reusable even after several cleaning cycles. Sartocon ECO ultrafilters will be available in Slice, Sartocon, and Sartocube formats for preferred nominal molecular weight cutoffs of 1 0, 30, and 1 00 kD in a cassette design. Sartorius Stedim Biotech, 800.368.7178, www.sartorius-stedim.com.

MULTI-WAY FLUIDIC CONNECTIONS

The Mitos In-line connector system from Dolomite provides in-line sealing and accurate alignment between tubes, enabling uninterrupted liquid flow. Available in three standard sizes: A-, 8-, and 12-way, the Mitos In-line connector operates over a wide temperature and pressure range, providing chemical compatibility. A low dead volume reduces the risk of crosscontamination between fluid samples, thereby maintaining experimental integrity. The technology benefits a broad range of applications, including chemical and biological analysis, parallel microfluidic processing, providing multi-way fluidic connections between various laboratory equipment. The connectors also are compatible with a variety of polymeric tubes including PTFE, FEP, and PEEK. Custom sizes and geometries also are available. Dolomite, +44 (0)1 763 246125, www. dolomite-microfluidics.com.

MOBILE PROCESSING STATION

GE Healthcare's ReadyKart mobile processing station is a flexible cart for the quick configuration of a wide range of sterile and disposable fluid processing systems for product and process development or pilot manufacturing. The setup with disposable ReadyToProcess components saves time, and with its nesting capabilities, the carts can be combined, adding yet more flexibility. The ReadyKart supports the use of GE Healthcare's ReadyToProcess equipment, which provides ready-to-use tools for all process stages, from fermentation, through to chromatography and filtration. GE Healthcare, www.gelifesciences.com/ readytoprocess.

BIOLOGICAL SHAKERS

New Brunswick Scientific manufactures a wide range of biological shakers, with benchtop, floor standing, or space-saving stackable models, offered with or without incubation. Refrigerated models also are offered. Innova Shakers with Triple-Eccentric Drive provide good performance, even when fully loaded and running at top speed. Advanced programming capabilities allow set-it and forget-it convenience. Optional photosynthetic lighting, gassing, humidity monitoring, and UV germicidal lights enable a broad range of applications. The economical Excella Shaker line (shown), is also available with membrane keypad and counterbalanced drive for accurate control and simple operation.

New Brunswick Scientific, 800.631.5417, www.nbsc.com.

JACKETED REACTOR SYSTEMS

Syrris has developed optional upgrades to its range of Atlas automated synthesis systems. The introduction of new stainless steel reactors and a high temperature upgrade kit has increased system flexibility, making the Atlas product range suitable fora broader spectrum of applications. Using the same jacketed vessel damp, oil drain unit, and fluid pipe connectors as the Atlas Potassium system, the standard glass vessel can be easily exchanged for the stainless steel version in less than a minute. Available in sizes from 1 0O mL to 5 L, an integrated bottom outlet valve compensates for any thermal expansion, while the torispherical profile and consistent length-to-diameter ratio mimics the dimensions of large-scale plant reactors. Syrris, +44 1763 242555, www.syrris.com.

GLASS REACTOR

The Advanced-Flow LF from Corning Incorporated is a flexible, low-flow glass reactor that enables a cost-effective transition to higher-volume, continuousflow chemical processing. The Corning Advanced-Flow reactors can continuously stream chemical reactants together with integrated heat exchange. Engineered glass fluidic modules form the basis of the reactor, providing mixing and heat exchange not possible in batch reactors used today. The modules are constructed into customized reactors that can be scaled up to industrial scale production banks according to customer specifications.

Corning Incorporated, 607.974.9000, www.corning.com.